Evaluation of Serum and Urinary Angiogenic Factors in Patients with Endometriosis

• DOI: 10.1111/j.1600-0897.2007.00535.x
• Publication Date: 2007-10-27T04:05:01Z
• Authors: Si Hyun Cho; Yoon Jin Oh; Anna Nam; Hye Yeon Kim; Joo Hyun Park; Jae Hoon Kim; Ki Hyun Park; Dong Je Cho; Byung Seok Lee
• Keywords: Adult; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Tumor Necrosis Factor-alpha; Endometriosis; 610; Middle Aged; 3. Good health; 618; 03 medical and health sciences; 0302 clinical medicine; Humans; Angiogenesis Inducing Agents; Female

The aim of this study was to evaluate serum and urinary levels vascular endothelial growth factors, tumor necrosis factor-alpha (TNF-alpha), soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis.During surgery for pelvic pain, mass or infertility, urine were collected. Of 70 patients, 46 had histology-proven endometriosis 24 without participated as controls.Serum TNF-alpha sFlt-1 corrected creatinine excretion significantly increased the group (P=0.001 P=0.011 respectively). Serum higher minimal-to-mild disease (P=0.014 P=0.015 respectively), where moderate-to-severe (P<0.001).The pathogenesis seems be different. Increased indicate that may have an important role inhibiting angiogenic process disease.