HuPho: the human phosphatase portal

• DOI: 10.1111/j.1742-4658.2012.08712.x
• Publication Date: 2012-07-17T08:46:02Z
• Authors: Susanna Liberti; Francesca Sacco; Alberto Calderone; Livia Perfetto; Marta Iannuccelli; Simona Panni; Elena Santonico; Anita Palma; Aurelio P. Nardozza; Luisa Castagnoli; Gianni Cesareni
• Keywords: Proteomics; Internet; 0303 health sciences; Settore BIO/18 - GENETICA; Computational Biology; Information Storage and Retrieval; Phosphoric Monoester Hydrolases; Substrate Specificity; 03 medical and health sciences; Humans; Phosphorylation; Databases, Protein; Protein Binding

Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post‐translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text‐mining‐assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it.