ATTEMPTS TO UTILIZE BACTERIOPHAGE TO COMBAT SALMONELLA ENTERICA SEROVAR ENTEMTIDIS INFECTION IN CHICKENS

• DOI: 10.1111/j.1745-4565.2001.tb00305.x
• Publication Date: 2007-04-03T15:32:32Z
• Authors: IAN B. SKLAR; ROLF D. JOERGER
• Keywords: Phage typing; Salmonella enterica; Cecum; Phage therapy

ABSTRACT Bacteriophage capable of lysing a nalidixic acid‐resistant Salmonella enterica serovar Enteritidis strain (Se E Nal r ) were tested for the ability to reduce cecal counts in young chickens infected with bacterium. Qualitative analysis cloacal swabs suggested that phage treatment can possibly shedding Se , but average between 10 5 and 7 cfu per g cecum obtained even from phage‐treated 14‐day old birds when more than plaque forming units present gram content. The generally 0.3 1.3 orders magnitude lower untreated controls birds. difference was statistically not significant three animal trials, two trials using feed particles as delivery vehicles phage. Although some cecae had developed resistance used, factors other must have contributed failure substantially counts.