Supersensitivity to substance P and physalaemin in rat salivary glands after denervation or decentralization

• DOI: 10.1111/j.1748-1716.1982.tb07102.x
• Publication Date: 2008-12-09T20:14:51Z
• Authors: JÖRGEN EKSTRÖM; CLAES WAHLESTEDT
• Keywords: Eledoisin; Exocrine gland

Substance P, a putative neurotransmitter in mammals, and physalaemin, present the skin of an amphibian, are both undecapeptides belong to family tachykinins. The secretory effect these tachykinins on parotid submaxillary glands rat was examined. Dose‐response curves showed that unoperated maximal responses were obtained intravenous dose 5–10μg/kg tachykinins, amount saliva secreted from gland twice gland, physalaemin more potent than substance P. Parasympathetic denervation decentralization caused marked sensitization as judged by lowered threshold doses for secretion increased series submaximal 3 weeks postoperatively. Sensitization less after sympathetic decentralization; caused, fact, no while degree about same two types operation. acted directly cells not exerted via cholinergic, α‐adrenergic or β‐adrenergic receptors. pattern found study, different operation is similar previously cholinergic agonists agonist. Studies others have shown peptidergic receptors share common intracellular pathway with receptors, whereas use another pathway. In study it suggested this arrangement importance development supersensitivity.