Epidemiological, Clinical, and Neuropathological Study of Apolipoprotein E Genotype in Alzheimer's Disease

• DOI: 10.1111/j.1749-6632.1996.tb32592.x
• Publication Date: 2006-12-18T05:17:25Z
• Authors: BRADLEY T. HYMAN; TERESA GOMEZ‐ISLA; G. WILLIAM REBECK; MEGAN BRIGGS; HAEYONG CHUNG; HOWARD L. WEST; STEVEN GREENBERG; STINA MUI; SUSAN NICHOLS; ROBERT WALLACE; JOHN H. GROWDON
• Keywords: Apolipoprotein E; Neuropathology

Our studies of the APOE genotype in AD confirm a strong association epsilon 4 allele with development and decreased risk associated 2. From clinical/neuropathological perspective, major effects are to lower age onset increase amount A beta deposit brain. Neither rate progression nor number neurofibrillary tangles were affected. We also carried out longitudinal population-based assessment determine for developing cognitive impairment someone general population based on genotype. about 1.4-fold increased risk, 2 1.7-fold risk. Thus, inheritance is biological factor AD, but it has limited utility as prognostic indicator dementia an individual.