Evidence for a difference in mechanism of action between fenfluramine- and amphetamine-induced anorexia

• DOI: 10.1111/j.2042-7158.1973.tb09114.x
• Publication Date: 2011-04-12T21:59:07Z
• Authors: Sune Jespersen; J Scheel-Krüger
• Keywords: Anorexia; Methysergide; Anorectic; Dextroamphetamine

Abstract The influence of drugs, active on 5-hydroxytryptamine (5-HT) mechanisms, has been examined the anorexigenic activity fenfluramine and (+)-amphetamine in rats trained to consume their daily food ration during 6 h. Chlorimipramine, which inhibits re-uptake mechanisms central 5-HT neurons, blocking drugs methergoline methysergide were used. Fenfluramine, 7.5 mg kg−1, amphetamine, 2.5 given 1/2 h before feeding reduced intake following 2 approximately 40% compared with control days. Pretreatment optimal dose (1 kg−1) produced only a weak but significant antagonism amphetamine anorexia, whereas anorexia was strongly antagonized by all doses tested (0.3, 1 3 kg−1). Methysergide (0.1, 0.3, showed no against or anorexia. Chlorimipramine strong antagonistic effect amphetamine. In contrast highest chlorimipramine (20 potentiated present results together other evidence discussed support conclusion that are involved seems mainly correlated catecholamine dependent mechanisms.