Comparative study on the sintered porous A‐type carbonate apatite, B‐type carbonate apatite, and hydroxyapatite

• DOI: 10.1111/jace.20389
• Publication Date: 2025-01-25T03:54:14Z
• Authors: Vincent Irawan; Kaori Akaike; Hayato Laurence M...; Yasutaka Anraku; Shinichi Sotome; Atsushi Okawa; Toshitaka Yoshii; Toshiyuki Ikoma

Abstract There are two types of carbonated apatite (cap): A‐type and B‐type, where carbonate ions substitute for hydroxyl sites in A‐CAp phosphate B‐CAp. Despite the known capacity CAp supporting activities bone cells, distinct potential B‐CAp as porous grafts is unclear. This study aimed to fabricate evaluate their biological vitro vivo compared stoichiometric hydroxyapatite (HAp). Gelatin‐casting freeze‐drying followed by sintering were used produce A‐ with high porosity ∼70%, pore sizes ∼100 µm, strength < 3 MPa. The contents 3.83 4.5 wt%, respectively, determined thermal gravimetric analysis calculations based on decomposition reactions. dissolved faster than HAp. had a higher affinity albumin but poorer osteoblastic cell attachment, while both lower proliferation rates After 2 weeks implantation vivo, HAp showed limited formation, whereas demonstrated ingrowth. Notably, enhanced osteoclast maturation. Both degradable after 8 post‐implantation. Structural features substitution elicit different output physicochemical, osteoconductivity, degradability.