Development of a feed additive to reduce caecal Campylobacter jejuni in broilers at slaughter age: from in vitro to in vivo , a proof of concept

• DOI: 10.1111/jam.12053
• Publication Date: 2012-10-30T08:05:24Z
• Authors: E. Grilli; F. Vitari; C. Domeneghini; A. Palmonari; G. Tosi; P. Fantinati; P. Massi; A. Piva
• Keywords: 0301 basic medicine; 2. Zero hunger; Animal Feed; Sorbic Acid; Thymol; BROILERS; BOTANICALS; CAMPYLOBACTER JEJUNI; Campylobacter jejuni; 03 medical and health sciences; Campylobacter Infections; Eugenol; Animals; Food Additives; Intestinal Mucosa; Propionates; Cecum; Chickens; Poultry Diseases

In vitro and in vivo challenge studies were undertaken to develop an in-feed additive of microencapsulated propionic, sorbic acids pure botanicals control Campylobacter jejuni broilers at slaughter age.Organic (OA) tested against Camp. jejuni, whereas vivo, chickens fed either a diet, or increasing doses the for 42 days (experiment 1); second experiment, received 0.1 0.3% from day 0 21 22 42. The consistently reduced caecal counts any given dose (exp. 1) inclusion plan 2). Moreover, it was able reduce number goblet cells modify mucin glycoconjugates biosynthesis pattern.We developed that effective reducing slaughter-age even low (0.1%). That efficacy result synergistic action between OA botanicals.This study provides strategy and, as consequence, improve safety food chain. data suggest treatment limited last weeks before would allow save on throughout whole production cycle.