Chitosan-protein scaffolds loaded with lysostaphin as potential antistaphylococcal wound dressing materials

• DOI: 10.1111/jam.12568
• Publication Date: 2014-06-10T12:53:26Z
• Authors: P. Szweda; G. Gorczyca; R. Tylingo; J. Kurlenda; J. Kwiecinski; S. Milewski
• Keywords: Lysostaphin; Wound treatment

The development of technology for preparing chitosan-protein scaffolds loaded with lysostaphin, which potentially could be used as dressing wound treatment and soft tissue infections caused by Staphylococcus aureus.The unique chitosan solubilization using gaseous CO(2) instead organic or inorganic acids was the incorporation enzyme that exhibits bactericidal activity against staphylococci, within structure sponges. developed lysostaphin revealed high antistaphylococcal activity, has been confirmed a large (n = 143) collection clinical (skin infections) animal (bovine mastitis) isolates these bacteria, including MRSA. No change lyophilized materials observed during half-year storage at 4°C.The are potential candidates biologically active, materials.Staphylococci belong to most popular burdensome aetiological factors tissues infections. possible solution problems associated