In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii

• DOI: 10.1111/jam.12970
• Publication Date: 2015-10-13T16:41:51Z
• Authors: A. Goc; A. Niedzwiecki; M. Rath
• Keywords: Borrelia garinii; Baicalein; Borrelia afzelii

Aims: Little is known about the effects of phytochemicals against Borrelia sp.causing Lyme disease.Current therapeutic approach to this disease limited antibiotics.This study examined anti-borreliae efficacy several plantderived compounds and micronutrients.Methods Results: We tested 15 micronutrients three morphological forms burgdoferi garinii: spirochetes, latent rounded biofilm.The results showed that most potent substances spirochete B. burgdorferi garinii were cis-2-decenoic acid, baicalein, monolaurin kelp (iodine); whereas, only baicalein revealed significant activity biofilm.Moreover, did not cause statistically cytotoxicity human HepG2 cells up 125 lg ml À1 20 .Conclusions: The effective antimicrobial all two sp. monolaurin.This might indicate presence fatty acid phenyl groups important for comprehensive antibacterial activity.Significance Impact Study: This reveals potential as an tool in fight species causing disease.