Lactobacillus rhamnosusinhibitsCandida albicansvirulence factorsin vitroand modulates immune system inGalleria mellonella

• DOI: 10.1111/jam.13324
• Publication Date: 2016-10-13T16:20:15Z
• Authors: F.C. Ribeiro; P.P. de Barros; R.D. Rossoni; J.C. Junqueira; A.O.C. Jorge
• Keywords: Galleria mellonella; Lactobacillus rhamnosus; Filamentation

The aim of this study was to evaluate the potential anti-Candida effects Lactobacillus rhamnosus ATCC 9595 on Candida albicans 18804 using in vitro and vivo models.The analysis evaluated L. C. albicans's biofilm formation by CFU count metabolic activity, filamentation capacity, adhesion (ALS3 HWP1) transcriptional regulatory gene (BCR1 CPH1) expression. results showed that both cells supernatant reduced formation, In study, treatment with increased 80% survival Galleria mellonella larvae infected albicans. Furthermore, recruited haemocytes into haemolymph (2·1-fold increase).Lactobacillus negatively regulating all studied genes. protected G. against experimental candidiasis vivo.This is first report properties 9595. strain has immunomodulatory model protects pathogens.