Para‐psychobiotic Lactobacillus gasseri CP 2305 ameliorates stress‐related symptoms and sleep quality

• DOI: 10.1111/jam.13594
• Publication Date: 2017-09-26T07:28:36Z
• Authors: K. Nishida; D. Sawada; T. Kawai; Y. Kuwano; S. Fujiwara; K. Rokutan
• Keywords: Lactobacillus gasseri; Sleep

To confirm the stress‐relieving effects of heat‐inactivated, enteric‐colonizing Lactobacillus gasseri CP2305 (paraprobiotic CP2305) in medical students taking a cadaver dissection course. Healthy (21 males and 11 females) took paraprobiotic daily for 5 weeks during The General Health Questionnaire Pittsburgh Sleep Quality Index were employed to assess stress‐related somatic symptoms sleep quality respectively. aggravation stress‐associated was observed female (P = 0·029). improved group 0·038), particularly men 0·004). Among men, shortened latency 0·035) increased duration 0·048). Diarrhoea‐like also effectively controlled with 0·005) men. Thus, we sex‐related differences CP2305. In addition, affected growth faecal Bacteroides vulgatus Dorea longicatena, which are involved intestinal inflammation. is potential that regulates stress responses, its beneficial may depend on specific cell component(s). This study characterizes para‐psychobiotic humans.