Use of polyvalent bacteriophages to combat biofilm ofProteus mirabiliscausing catheter-associated urinary tract infections

• DOI: 10.1111/jam.14026
• Publication Date: 2018-06-20T20:52:56Z
• Authors: A. Maszewska; M. Zygmunt; I. Grzejdziak; A. Różalski
• Keywords: Urinary catheter

Catheter‐associated urinary tract infections (CAUTI) caused by Proteus mirabilis are very difficult to treat due the ability of biofilm formation and drug resistance these bacteria. The aim this study was assess antibiofilm activity phages develop phage cocktail combat P. strains. Planktonic forms biofilms 50 tested uropathogenic strains showed different sensitivity 13 used. Phages 39APmC32, 65APm2833 72APm5211 presenting strong were selected as components. cocktails similar or slightly higher than that most active phage. A three‐phage inhibited destroyed same number 2–3 more compared a single components did not block each other's activity. potential developed anti‐P. an agent proved. In study, three broad host range selected. Additionally, high stability viruses makes them useful tool for controlling biofilms.