Dietary supplementation with Bacillus mixture modifies the intestinal ecosystem of weaned piglets in an overall beneficial way
Jejunum
Bacillus licheniformis
Basal (medicine)
DOI:
10.1111/jam.14782
Publication Date:
2020-07-12T01:49:30Z
AUTHORS (7)
ABSTRACT
Aims This study was conducted to investigate the effects of dietary supplementation with a mixture Bacillus, which serves as an alternative antibiotics on intestinal ecosystem weaned piglets. Methods and Results We randomly assigned 120 piglets three groups: control group (a basal diet), probiotics diet supplemented 4 × 109 CFU per gram Bacillus licheniformis-Bacillus subtilis mixture; BLS mix), 0·04 kg t−1 virginiamycin, 0·2 colistin 3000 mg kg−1 zinc oxide). All groups had five replicates eight replicate. On days 7, 21 42 trial, intestine tissue digesta samples were collected determine morphology, gut microbiota bacterial metabolite composition, expression genes related barrier function inflammatory status. The results showed that mix decreased jejunum crypt depth, while increased ileum villus height depth ratio. Simpson's diversity index in relative abundances o_Bacteroidetes f_Ruminococcaceae, but Blautia Clostridium. Dietary also modified concentration several metabolites compared group. In addition, upregulated level E-cadherin colon pro-inflammatory cytokines TLR-4 colon. Lastly, Spearman's rank-order correlation revealed potential link between alterations health parameters Conclusion These findings suggest modifies advantages such modifications terms are discussed. Significance Impact Study Weaning is most important transition period piglet growth development. probiotic effective antibiotics, beneficial improving
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