Effects of the prebiotic inulin‐type fructans on post‐antibiotic reconstitution of the gut microbiome

• DOI: 10.1111/jam.14827
• Publication Date: 2020-08-28T08:33:53Z
• Authors: C. Tao; W. Zeng; Q. Zhang; G. Liu; F. Wu; H. Shen; W. Zhang; H. Bo; H. Shao
• Keywords: Prebiotic; Dysbiosis

Aims Interventions using prebiotic inulin-type fructans (ITFs) are widely prescribed to modulate the gut microbiota composition and activity promote health. However, impacts of ITFs on post-antibiotic reconstitution microbiome remain incompletely understood. The aim present study was investigate effects supplementation intestinal inflammation, colonic transcriptome after antibiotic treatment. Methods Results Male BALB/c mice were subjected an cocktail (ABx) treatment for 7 days, their microbiomes then reconstituted either spontaneously or with (5%) 14 days. Our data showed that delayed recovery antibiotic-induced colitis compared spontaneous recovery. Neither nor could restore microbial community at genus level back its initial composition. increased relative abundance some beneficial bacteria butyrate levels, but resulted in selective blooms opportunistic pathogens elevated pathways associated diseases linked function. Both nearly profile a certain extent; however, restoration immunoglobulin genes Conclusion These consumption did not always lead might potential adverse context dysbiosis. Significance Impact Study findings highlighted caution is required when supplementing homeostasis dysbiosis resulting from broad-spectrum antibiotics.