Cardiac Autoantibody Levels Predict Recurrence Following Cryoballoon‐Based Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation Patients

• DOI: 10.1111/jce.12665
• Publication Date: 2015-03-19T07:29:24Z
• Authors: MUHAMMED ULVI YALCIN; KADRI MURAT GURSES; DUYGU KOCYIGIT; SACIT ALTUG KESIKLI; MUHAMMET DURAL; BANU EVRANOS; HIKMET YORGUN; LEVENT SAHINER; ERGUN BARIS KAYA; MEHMET ALI OTO; DICLE GUC; KUDRET AYTEMIR; NECLA OZER
• Keywords: Paroxysmal atrial fibrillation

Cardiac Autoantibodies and AF Recurrence Introduction Recent evidence has suggested that autoantibodies may play an important role in the development of atrial fibrillation (AF). The predictive value preprocedural against beta‐1 adrenergic receptor (anti‐β1‐R) M2‐muscarinic acetylcholine (anti‐M2‐R) for recurrence following cryoballoon‐based pulmonary vein isolation (PVI) is still unclear. We aimed to determine anti‐β1‐R anti‐M2‐R levels recurrence. Methods Eighty patients (mean age 54.25 ± 7.70 years; 40% female) with paroxysmal preserved left ventricular function who underwent PVI were included study. Preprocedural measured ELISA. Results At 1‐year follow‐up after ablation, late was observed 17 (21.25%) patients. In Cox regression model, including number antiarrhythmic drugs, early recurrence, >159.88 ng/mL, >277.65 duration, volume index, only ng/mL (HR: 4.281, P = 0.039) 4.313, 0.030) found be independent predictors Anti‐β1‐R level shown predict a sensitivity 70.59% specificity 90.48%. A cut‐off 277.65 predicted 95.24%. Conclusion serum are Detection serve as novel method determination not benefit from PVI.