Overweight and obesity in patients with atrial fibrillation: Sex differences in 1‐year outcomes in the EORP‐AF General Pilot Registry

• DOI: 10.1111/jce.13428
• Publication Date: 2018-01-18T12:00:27Z
• Authors: Giuseppe Boriani; Cécile Laroche; Igor Diemberger; Elisa Fantecchi; Joan Meeder; Malgorzata Kurpesa; Monica Mariana Ba...; Marco Proietti; Luigi Tavazzi; Aldo P. Maggioni; Gregory Y. H. Lip
• Keywords: Obesity paradox

Abstract Background The impact of overweight and obesity on outcomes in “real world” patients with atrial fibrillation (AF) is not fully defined. Second, sex differences AF may also exist. Methods results aim was to investigate at 1 year follow‐up for enrolled the EORP‐AF Registry, according BMI (kg/m 2 ), comparing normal (18.5 < 25 kg/m (25 30 ) (≥ relation differences. Among 2,540 EORP (38.9% female; median age 69) data available, 720 (28.3%) had a BMI, 1,084 (42.7%) were overweight, 736 (29.0%) obese. Obese younger more prevalent diabetes mellitus hypertension (P 0. 001). One‐year showed that all‐cause mortality significantly different among female (9.3% 5.3% 4.3 % obese, P = 0.023), but male 0.748). composite outcome thromboembolic events death different, being lower obese females 0.035). patients, bleeding frequent subjects On multivariable Cox analysis, independently associated mortality. Conclusions are common better (a finding previously reported as “obesity paradox”), while no significant detected patients. Final model found increasing increased risk death; conversely, comorbidities persisted major determinants.