Cessation of pacing in super‐responders of cardiac resynchronization therapy: A randomized controlled trial

• DOI: 10.1111/jce.13711
• Publication Date: 2018-08-14T11:24:48Z
• Authors: Yixiu Liang; Qingqing Wang; Mingliang Zhang; Jingfeng Wang; Haiyan Chen; Ziqing Yu; Xue Gong; Yangang Su; Junbo Ge
• Keywords: Male; Middle Aged; Ventricular Function, Left; 3. Good health; Cardiac Resynchronization Therapy; Ventricular Dysfunction, Left; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Withholding Treatment; Humans; Female; Single-Blind Method; Prospective Studies; Aged; Retrospective Studies

Abstract Background The consequence of cessation biventricular pacing in super‐responders cardiac resynchronization therapy (CRT) has not been fully investigated. Methods In this prospective, single‐blinded clinical trial, 21 were randomly assigned to the ceased (CeP, 11 patients) group or continued (CoP, 10 group. Patients randomized CeP underwent pacing. New York Heart Association (NYHA) class, quality life (QOL) assessed with Minnesota questionnaire, 6‐minute walking distance (6MWD), left ventricular end systolic volume (LVESV), end‐diastolic (LVEDV), and ejection fraction (LVEF) compared between groups at 3‐ 6‐month follow‐up. Results No significant difference was observed CoP regarding NYHA QOL, 6MWD, LVESV, LVEDV, LVEF after 3 months (all P > 0.05). After 6 months, there existed no regard LVEDV 0.05); however, significantly lower than that (0.49 ± 0.10 vs 0.60 0.11, = 0.04), reduced baseline value randomization 0.54 0.06, 0.04). Conclusion CRT Super‐responders should receive continued, long‐term preserve recovered LV function.