Acute lesion extension following pulmonary vein isolation with two novel single shot devices: Pulsed field ablation versus multielectrode radiofrequency balloon

• DOI: 10.1111/jce.16001
• Publication Date: 2023-07-20T21:10:04Z
• Authors: Ilaria My; Marc D. Lemoine; Mahi Butt; Celine Mencke; Fabian W. Loeck; Julius Obergassel; Laura Rottner; Jan‐Per Wenzel; Ruben Schleberger; Julia Moser; Fabian Moser; Paulus Kirchhof; Bruno Reissmann; Feifan Ouyang; Andreas Rillig; Andreas Metzner
• Keywords: Male; Aged, 80 and over; Treatment Outcome; Catheters; Pulmonary Veins; Atrial Fibrillation; Catheter Ablation; Humans; Female; Middle Aged; Aged

Pulsed-field ablation (PFA) and the multielectrode radiofrequency balloon (RFB) are two novel technologies to perform pulmonary vein isolation (PVI). It is currently unknown whether these differ in lesion formation extent. We compared acute extent after PVI induced by PFA RFB measuring low-voltage area high-density maps release of biomolecules reflecting cardiac injury.PVI was performed with a pentaspline catheter (FARAPULSE) applying or compliant (HELIOSTAR). Before mapping CARTO 3 performed. In addition, blood samples were taken before transseptal puncture post-PVI remapping serum concentrations high-sensitive Troponin I quantified immunoassay.Sixty patients undergoing (n = 28, age 69 ± 12 year, 60% males, 39.3% persistent atrial fibrillation [AF]) 32, 65 13 53% 21.9% AF) evaluated. Acute achieved all both groups. Mean number pulses 34.2 4.5 mean applications 8.5 per patient. Total posterior significantly larger (20.7 7.7 cm²) than (7.1 2.09 cm²; p < .001). Accordingly, for each PV resulted lesions versus (LSPV 5.2 2.7 vs. 1.9 0.8 cm², LIPV 5.5 2.3 RSPV 4.7 1.6 0.5 RIPV 5.3 2.1 0.7 cm,² respectively; subset 38 patients, increase hsTropI higher (625 138 pg/mL, n 28) (148 36 10; .049) supporting evidence PFA.PFA delivers areas troponin upon successful RFB-based this single-center series.