High‐phosphorus diet controlled for sodium elevates blood pressure in healthy adults via volume expansion

• DOI: 10.1111/jch.14182
• Publication Date: 2021-01-24T12:24:40Z
• Authors: Jia‐ying Zhang; Huai‐zhou You; Meng‐jing Wang; Qian Zhang; Xin‐yu Dong; Jing‐fang Liu; Jing Chen
• Keywords: Adult; Male; 2. Zero hunger; aldosterone; Cross-Over Studies; Sodium; blood pressure; Blood Pressure; Phosphorus; fibroblast growth factor 23; Diet; 3. Good health; 03 medical and health sciences; nutrition; 0302 clinical medicine; RC666-701; atrial natriuretic peptide; Hypertension; parathyroid hormone; Diseases of the circulatory (Cardiovascular) system; Humans; Prospective Studies

Abstract Whether increasing exposure to dietary phosphorus can lead adverse clinical outcomes in healthy people is not clear. In this open‐label prospective cross‐over study, we are explore the impact of various intake on mineral, sodium metabolisms and blood pressure young adults. There were 3 separate study periods 5 days, each with a days washout period between different diets interventions. Six male volunteers normal nutrition status recruited Phase I Clinical Research Center sequentially exposed following diets: (a) normal‐phosphorus diet (NPD): 1500 mg/d, (b) low‐phosphorus (LPD): 500 (c) high‐phosphorus (HPD): 2300 mg/d. HPD induced significant rise daily average serum phosphate (1.47 ± 0.02 mmol/L [4.56 0.06 mg/dl]) compared NPD (1.34 [4.15 mg/dL]) LPD (1.17 [3.63 ( p < .05). Daily levels parathyroid hormone fibroblast growth factor 23 significantly higher, 1,25(OH) 2 D was remarkably lower than those LPD. decrease aldosterone an increase atrial natriuretic peptide level The 24‐hour urine volume subjects less that subjects. increased systolic by 6.02 1.24 mm Hg 8.58 1.24mm Our provides first evidence 5‐day induce elevation SBP adults, which may due expansion.