A randomized, double‐blind clinical trial to evaluate the blood pressure lowing effect of low‐sodium salt substitution on middle‐aged and elderly hypertensive patients with different plasma renin concentrations

• DOI: 10.1111/jch.14396
• Publication Date: 2021-12-30T06:48:24Z
• Authors: Li Che; Wei Song; Ying Zhang; Yan Lu; Yunpeng Cheng; Yinong Jiang
• Keywords: Plasma renin activity; Subgroup analysis

Abstract This study aimed to evaluate the blood pressure (BP) lowing effect of low‐sodium (LS) salt substitution and how influenced by plasma renin concentration (PRC) on middle‐aged elderly hypertensive patients. Three hundred fifty‐two hypertensives were randomized at a 1:1 ratio into LS group normal (NS) group. We compared intergroup changes observed in office measurement (OBPM) home (HBPM). Then, all patients divided tertiles according baseline PRC, aldosterone concentration, aldosterone/renin (ARR), OBPM HBPM across three tertile subgroups. Follow‐up surveys completed 322 The net reduction systolic OBPM, HBPM, diastolic was −6.6, −4.6, −2.3 mmHg, respectively (all P < .05), −1.8 mmHg ( = .068). There more significant among low PRC subgroup than high subgroup. no differences between subgroups when grouped concentration. ARR larger that is effective reducing may offer non‐pharmaceutical therapy for Baseline be marker predict BP response after restriction.