Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester

• DOI: 10.1111/jch.14601
• Publication Date: 2022-12-07T18:53:43Z
• Authors: Yongmei Shen; Jiasong Cao; Liying Yao; Shanshan Li; Xiaomin Zhao; Wen Li; Zhuo Wei; Lei Zhang; Jianxi Wang; Ying Chang
• Keywords: Second trimester

Abstract Preeclampsia (PE) is the most common medical complication during pregnancy and second leading cause of maternal death worldwide. However, a better predictive model PE remains to be explored. A total 15 severe preeclampsia (sPE) 75 healthy control patients were included in this study. Patient data was obtained from September 2019 2021. Nuchal translucency (NT) crown‐rump length (CRL) fetus acquired by ultrasound. Maternal blood samples collected at 11 +0 13 +6 weeks gestation. Chemiluminescent immunoassays used detect serum testosterone (T) estradiol (E2) levels. Time‐resolved fluorescence analysis examine levels pregnancy‐associated plasma protein (PAPPA) β‐human chorionic gonadotrophin (β‐HCG) protein. The sPE group exhibited increased T levels, decreased E2 E2/T ratios 14 gestation, compared with group. ratio showed positive linear correlation CRL pregnant women. Body‐mass‐index (BMI), T, determined main factors that affected occurrence 12‐week gestation period time point. receiver operating characteristic (ROC) curve revealed AUC .717. imbalanced had specific intrinsic relevance sPE, which suggests them as novel predictors sPE.