Association Between Longitudinal Changes in Left Ventricular Structure and Function and 24‐Hour Urinary Free Cortisol in Essential Hypertension

• DOI: 10.1111/jch.14979
• Publication Date: 2025-02-26T05:11:13Z
• Authors: Gao‐Zhen Cao; Jia‐Yi Huang; Qing‐Shan Lin; Run Wang; Cong Chen; Jian‐Cheng Xiu; Kai‐Hang Yiu
• Keywords: Essential hypertension; Ventricular remodeling

ABSTRACT This study aimed to investigate the associations between 24‐hour urinary cortisol levels (24 h‐UFC) and alterations in left ventricular (LV) structure function patients with essential hypertension. A prospective cohort was conducted, including 315 hypertension who underwent baseline 24 h‐UFC measurement echocardiographic evaluation of mass (LVM), ejection fraction (LVEF), E/e′ ratio. Over a mean follow‐up period 28.54 ± 14.21 months, were grouped into tertiles based on levels. Higher significantly associated greater increases LVM E/e′, reflecting adverse LV remodeling diastolic dysfunction. These persisted after adjusting for potential confounders, age, gender, blood pressure, their changes during follow‐up. Moreover, highest tertile showed an increased prevalence hypertrophy, contrasting reduction observed lower tertiles. findings underscore independent role elevated driving cardiac structural functional