HOTAIRM1 as a potential biomarker for diagnosis of colorectal cancer functions the role in the tumour suppressor

• DOI: 10.1111/jcmm.12892
• Publication Date: 2016-06-16T11:00:56Z
• Authors: Ledong Wan; Jianlu Kong; Jinlong Tang; Yihua Wu; Enping Xu; Maode Lai; Honghe Zhang
• Keywords: Carcinoembryonic antigen

Abstract Recent studies have revealed many different long noncoding RNA s (lnc ), however, the investigation for their function and clinical value as tumour biomarkers has scarcely begun. Here, we found that expression of HOTAIRM 1 was reduced in colorectal cancer ( CRC ) tissues compared with matched normal tissues, plasma levels patients were less than controls. The cut‐off point chosen 0.003 a sensitivity 64.00% specificity 76.50% validation set. performance highly comparable to carcinoembryonic antigen CEA better CA 19‐9 125. combined assay raised 84.00%. knockdown resulted obvious changes cell proliferation related genes promoted proliferation. plays role suppressor ; Down‐regulation can serve biomarker , might provide promising diagnosis .