The long non‐coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell

• DOI: 10.1111/jcmm.13405
• Publication Date: 2017-11-29T17:34:41Z
• Authors: Yetao Xu; Yifan Lian; Yuanyuan Zhang; Shiyun Huang; Qing Zuo; Nana Yang; Yanzi Chen; Dan Wu; Lizhou Sun
• Keywords: Trophoblast

Abstract Despite progress in diagnostics and treatment for preeclampsia, it remains the foremost cause of maternal foetal perinatal morbidity mortality worldwide. Over recent years, various lines evidence have emphasized long non‐coding RNA s (lnc s) which function as an innovative regulator biological behaviour, exemplified by proliferation, apoptosis metastasis. However, role lnc has not been well described preeclampsia. Here, we identified a , PVT 1 whose expression was down‐regulated qRT ‐ PCR analyses severe The effects on development were studied after suppression overexpression HTR ‐8/ SV neo JEG 3 cells. knockdown notably inhibited cell proliferation stimulated cycle accumulation apoptosis. Exogenous significantly increased proliferation. Based analysis seq data, found that could affect numerous genes, then investigated regulatory mechanism trophoblast Further mechanistic implied action is moderately attributable to its repression ANGPTL 4 via association with epigenetic repressor Ezh2. Altogether, our study suggests play essential preeclampsia progression probably acts latent therapeutic marker; thus, might be useful prognostic marker when evaluating new therapies patients