INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway

• DOI: 10.1111/jcmm.13595
• Publication Date: 2018-03-08T03:22:40Z
• Authors: Ying Chen; Zeyu Sun; Mei Qi; Xiao Wang; Weifang Zhang; Chunyan Chen; Juan Liu; Weiming Zhao
• Keywords: HeLa

Abstract Cervical cancer continues to be among the most frequent gynaecologic cancers worldwide. The phosphoinositide 3‐kinase ( PI 3K)/protein kinase B AKT ) pathway is constitutively activated in cervical cancer. Inositol polyphosphate 4‐phosphatase type II INPP 4B) a phosphatase and considered negative regulatory factor of 3K/ pathway. 4B has diverse roles various tumours, but its role largely unknown. In this study, we investigated Overexpression HeLa, SiHa C33a cells inhibited cell proliferation, metastasis invasiveness CCK ‐8, colony formation, anchorage‐independent growth soft agar Transwell assay. reduced expression some essential proteins / SGK 3 including p‐ , 3, mTOR phospho‐p70S6K PDK 1. addition, overexpression decreased xenograft tumour nude mice. Loss protein was found more than 60% human carcinoma samples. conclusion, impedes proliferation by inhibiting activation two downstream molecules 3K pathway, 3. acts as suppressor cells.