Follistatin‐like protein 5 inhibits hepatocellular carcinoma progression by inducing caspase‐dependent apoptosis and regulating Bcl‐2 family proteins

• DOI: 10.1111/jcmm.13906
• Publication Date: 2018-09-26T06:00:15Z
• Authors: Chunlei Li; Lei Dai; Junfeng Zhang; Yujing Zhang; Yi Lin; Lin Cheng; Hongwei Tian; Xin Zhang; Qingnan Wang; Qianmei Yang; Yuan Wang; Gang Shi; Fuyi Cheng; Xiaolan Su; Yang Yang; Shuang Zhang; Dechao Yu; Yuquan Wei; Hongxin Deng
• Keywords: Follistatin; Bcl-2 Family; XIAP; Protein family

Hepatocellular carcinoma (HCC) is one of the most common and deadly malignant tumors in world, especially China. Follistatin-like protein 5 (FSTL5) a member FSTL family, which involved cell proliferation, migration, differentiation, embryo development. We aimed to investigate function underlying mechanism FSTL5 HCC. expression was determined by immunohistochemistry staining liver cancer tissue microarray (TMA) correlation between prognosis HCC patients analysed. Further proliferation assay, colony formation flow cytometry, xenograft tumor model were performed bioeffects vitro vivo. found that downregulated tissues positively correlated with at node metastasis stage I/II. Overexpression efficiently impaired growth both vivo an exogenous manner. Mechanistic investigation demonstrated promoted apoptosis caspase-dependent manner regulated Bcl-2 family proteins. These results indicate may be potential novel target for treatment, biomarker prognosis.