Repression of Noxa by Bmi1 contributes to deguelin‐induced apoptosis in non‐small cell lung cancer cells

• DOI: 10.1111/jcmm.13908
• Publication Date: 2018-09-26T05:44:08Z
• Authors: Wei Li; Xinfang Yu; Zhenkun Xia; Xinyou Yu; Li Xie; Xiaolong Ma; Huiling Zhou; Lijun Liu; Jian Wang; Yifeng Yang; Haidan Liu
• Keywords: BMI1

Abstract Deguelin, a natural rotenoid isolated from several plants, has been reported to exert anti‐tumour effects in various cancers. However, the molecular mechanism of this regulation remains be fully elucidated. Here, we found that deguelin inhibited growth non‐small cell lung cancer ( NSCLC ) cells both vitro and vivo by downregulation Bmi1 expression. Our data showed is highly expressed human tissues lines. Knockdown significantly suppressed proliferation colony formation. Deguelin treatment attenuated binding activity Noxa promoter, thus resulting transcription apoptosis activation. promoted expression enhanced deguelin‐induced apoptosis, whereas overexpression down‐regulated protein level apoptosis. Overall, our study demonstrated novel apoptotic for its cells.