Long noncoding RNA LINC00511 induced by SP1 accelerates the glioma progression through targeting miR‐124‐3p/CCND2 axis

• DOI: 10.1111/jcmm.14331
• Publication Date: 2019-04-12T02:39:22Z
• Authors: Chen Li; Hongjiang Liu; Jipeng Yang; Jiankai Yang; Liang Yang; Yuanyu Wang; Zhongjie Yan; Yuchen Sun; Xiaofeng Sun; Baohua Jiao
• Keywords: Transcription

Abstract Mounting evidence suggests the vital roles of long noncoding RNA (lncRNAs) in glioma. However, role LINC00511 gliomagenesis is still uncovered. Here, this study, we aim to investigate effects on glioma cancer phenotype and its deepgoing mechanism. Results indicated that was up‐regulated tissues cell lines, moreover overexpression positively correlated with poor prognosis advanced pathological stages. For upstream regulation, epigenetically by transcription factor specificity protein 1 (SP1). Gain loss functional experiments demonstrated promoted proliferation invasion cells vitro. The knockdown repressed tumour growth vivo. Mechanistically, regulated CCND2 expression via competitively sponging miR‐124‐3p. Overall, our finding illuminates induced SP1 accelerates progression through targeting miR‐124‐3p/CCND2 axis, constructing SP1/LINC00511/miR‐124‐3p/CCND2 axis.