Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids

• DOI: 10.1111/jcmm.14410
• Publication Date: 2019-05-24T09:23:08Z
• Authors: Man Zhang; Yuanyuan Gu; Shunwei Huang; Qiuyue Lou; Qiaomei Xie; Zhiwei Xu; Yangfan Chen; Faming Pan; Shengqian Xu; Shengxiu Liu; Jinhui Tao; Shuang Liu; Jing Cai; Peiling Chen; Long Qian; Chunhuai Wang; Chunmei Liang; Hailiang Huang; Haifeng Pan; Hong Su; Jian Cheng; Yuzhou Zhang; Wenbiao Hu; Yanfeng Zou
• Keywords: Adult; Male; Efficacy; DNA Copy Number Variations; efficacy; 610; Polymorphism, Single Nucleotide; polymorphism; 03 medical and health sciences; Systemic lupus erythematosus; systemic lupus erythematosus; Asian People; Gene Frequency; HSP90AB1; Humans; Lupus Erythematosus, Systemic; Genetic Predisposition to Disease; HSP90 Heat-Shock Proteins; Polymorphism; Glucocorticoids; Genetic Association Studies; 0303 health sciences; glucocorticoids; Copy number variation; copy number variation; Original Articles; 3. Good health; Case-Control Studies; Quality of Life; Female

The aim of our study was to assess the associations HSP90AB1 copy number variations (CNVs) with systemic lupus erythematosus (SLE) risk and glucocorticoids (GCs) efficacy, as well relationship between single-nucleotide polymorphisms (SNPs) GCs efficacy. CNVs SLE were analysed in 519 patients 538 controls. Patients treated followed up for 12 weeks divided into sensitive insensitive groups investigate effects (419 patients) SNPs (457 on efficacy GCs. Health-related quality life (HRQoL) also measured by SF-36 at baseline week explore CNVs/SNPs HRQoL improvements Chinese patients. Our results indicated a statistically significant association (PBH = 0.039), this more pronounced female subgroup 0.039). However, we did not detect But found marginal SNP rs13296 improvement Role-emotional, while strong enough survive multiple testing corrections. Collectively, findings suggest that is associated susceptibility. may be