Mesenchymal stem cell‐derived exosomes ameliorate erection by reducing oxidative stress damage of corpus cavernosum in a rat model of artery injury

• DOI: 10.1111/jcmm.14615
• Publication Date: 2019-09-12T04:28:40Z
• Authors: Yangzhou Liu; Shankun Zhao; Lianmin Luo; Jiamin Wang; Zhiguo Zhu; Qian Xiang; Yihan Deng; Zhigang Zhao
• Keywords: Male; 0301 basic medicine; Penile Erection; Mesenchymal Stem Cells; Muscle, Smooth; Original Articles; Arteries; Exosomes; Rats; 3. Good health; Rats, Sprague-Dawley; Disease Models, Animal; Oxidative Stress; 03 medical and health sciences; Erectile Dysfunction; Animals; Nitric Oxide Synthase; Carotid Artery Injuries; Penis

Erectile dysfunction (ED) is a common ageing male's disease, and vascular ED accounts for the largest proportion of all types ED. One mechanisms in clinic arterial insufficiency, which mainly caused by atherosclerosis, trauma surgical. Moreover, oxidative stress damage after tissue ischemia usually aggravated progress As new way acellular therapy, mesenchymal stem cell-derived exosomes (MSC-Exos) have great potential treatment. In current study, we explored mechanism MSC-Exos therapy rat model internal iliac artery injury-induced Compared with intracavernous (IC) injection phosphate-buffered saline injury, note, observed that both cells (MSCs) through IC could improve erectile function to varying degrees. More specifically, promote cavernous sinus endothelial formation, reduce organization damage, nitric oxide synthase smooth muscle content corpus cavernosum. With similar potency compared cell other unique advantages, MSC- Exos be an effective treatment ameliorate injury.