Prognostic power of a lipid metabolism gene panel for diffuse gliomas

• DOI: 10.1111/jcmm.14647
• Publication Date: 2019-09-02T04:54:21Z
• Authors: Fan Wu; Zheng Zhao; Rui‐Chao Chai; Yu‐Qing Liu; Guan‐Zhang Li; Hao‐Yu Jiang; Tao Jiang
• Keywords: Male; 0301 basic medicine; Brain Neoplasms; Original Articles; Glioma; Lipid Metabolism; Prognosis; 3. Good health; Cohort Studies; 03 medical and health sciences; Phenotype; Risk Factors; Multivariate Analysis; Humans; Female; Neoplasm Grading; Cell Division; Genes, Neoplasm; Proportional Hazards Models

AbstractLipid metabolism reprogramming plays important role in cell growth, proliferation, angiogenesis and invasion in cancers. However, the diverse lipid metabolism programmes and prognostic value during glioma progression remain unclear. Here, the lipid metabolism‐related genes were profiled using RNA sequencing data from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) database. Gene ontology (GO) and gene set enrichment analysis (GSEA) found that glioblastoma (GBM) mainly exhibited enrichment of glycosphingolipid metabolic progress, whereas lower grade gliomas (LGGs) showed enrichment of phosphatidylinositol metabolic progress. According to the differential genes of lipid metabolism between LGG and GBM, we developed a nine‐gene set using Cox proportional hazards model with elastic net penalty, and the CGGA cohort was used for validation data set. Survival analysis revealed that the obtained gene set could differentiate the outcome of low‐ and high‐risk patients in both cohorts. Meanwhile, multivariate Cox regression analysis indicated that this signature was a significantly independent prognostic factor in diffuse gliomas. Gene ontology and GSEA showed that high‐risk cases were associated with phenotypes of cell division and immune response. Collectively, our findings provided a new sight on lipid metabolism in diffuse gliomas.