A 3‐miRNA signature predicts survival of patients with hypopharyngeal squamous cell carcinoma after post‐operative radiotherapy

• DOI: 10.1111/jcmm.14702
• Publication Date: 2019-10-03T03:11:18Z
• Authors: Xinbo Xu; Zhongming Lu; Neil Gross; Guojun Li; Fenghua Zhang; Dapeng Lei; Xinliang Pan
• Keywords: Hypopharyngeal cancer

Abstract Since the prognosis of hypopharyngeal squamous cell carcinoma (HSCC) remains poor, identification miRNA as a potential prognostic biomarker for HSCC may help improve personalized therapy. In 2 cohorts with total 511 patients (discovery: N = 372 and validation: 139) after post‐operative radiotherapy, we used microarray qRT‐PCR to screen out significant miRNAs which might predict survival. Associations signature score these survival were performed by Kaplan‐Meier analysis multivariate Cox hazard model. Among 9 candidate, miRNAs, miR‐200a‐3p, miR‐30b‐5p, miR‐3161, miR‐3605‐5p, miR‐378b miR‐4451 up‐regulated, while miR‐200c‐3p, miR‐429 miR‐4701 down‐regulated validation. Moreover, high expression miR‐30b‐5p had significantly worse overall (OS) disease‐specific (DSS) than did those low (log‐rank P < .05). Patients high‐risk OS DSS low‐risk score. Finally, adjusting other important confounders, risk death owing has approximately 2‐fold increased in compared These findings indicated that 3‐miRNA‐based be novel independent given surgery supporting jointly HSCC.