Monophosphoryl lipid A alleviated radiation‐induced testicular injury through TLR4‐dependent exosomes

• DOI: 10.1111/jcmm.14978
• Publication Date: 2020-03-05T17:36:03Z
• Authors: Zhe Liu; Kun Cao; Zebin Liao; Yuanyuan Chen; Xiao Lei; Qun Wei; Cong Liu; Xuejun Sun; Yanyong Yang; Jianming Cai; Fu Gao
• Keywords: Male; 0303 health sciences; Original Articles; Abnormalities, Radiation-Induced; Exosomes; Toll-Like Receptor 4; Disease Models, Animal; Mice; 03 medical and health sciences; Lipid A; Radiation Protection; Testis; Animals; Humans

Abstract Radiation protection on male testis is an important task for ionizing radiation‐related workers or people who receive radiotherapy tumours near the testicle. In recent years, Toll‐like receptors (TLRs), especially TLR4, have been widely studied as a radiation target. this study, we detected that low‐toxicity TLR4 agonist monophosphoryl lipid A (MPLA) produced obvious effects mice testis. We found MPLA effectively alleviated structure damage and cell apoptosis induced by (IR). However, expression abundance differs lot in distinct cells tissues, seemed not to directly activate singling pathway Here, demonstrated brand new mechanism producing observed significant activation of macrophages after stimulation identified changes macrophage‐derived exosomes protein expression. proved treatment, played role protection, specially, G‐CSF MIP‐2 are core molecules effect.