Impact of chronic intermittent hypoxia on the long non‐coding RNA and mRNA expression profiles in myocardial infarction

• DOI: 10.1111/jcmm.16097
• Publication Date: 2020-11-20T21:13:51Z
• Authors: Chaowei Hu; Jing Li; Yunhui Du; Juan Li; Yunyun Yang; Yifan Jia; Lu Peng; Yanwen Qin; Yongxiang Wei
• Keywords: Hypoxia; Pathogenesis

Abstract Chronic intermittent hypoxia (CIH) is the primary feature of obstructive sleep apnoea (OSA), a crucial risk factor for cardiovascular diseases. Long non‐coding RNAs (lncRNAs) in myocardial infarction (MI) pathogenesis have drawn considerable attention. However, whether CIH participates modulation lncRNA profiles during MI yet unclear. To investigate influence on MI, cardiac damage was assessed by histology and echocardiography, mRNA integrated microarrays were screened. mouse model showed hypertrophy, aggravated inflammation fibrosis, compromised left ventricle function under CIH. Compared with normoxia, 644 lncRNAs 1084 differentially expressed mRNAs identified following 4 weeks, whereas 1482 990 altered at 8 weeks. Strikingly, reoxygenation after markedly affected 1759 778 mRNAs. Of these, 11 modulated restored validated qPCR. The GO terms KEGG pathways genes varied significantly lncRNA‐mRNA correlation further that lncRNAs, NONMMUT032513 NONMMUT074571 positively correlated ZEB1 negatively Cmbl. current results demonstrated causal between alternations suggesting might be responsible aggravation