3,6'‐disinapoyl sucrose attenuates Aβ1‐42‐ induced neurotoxicity in Caenorhabditis elegans by enhancing antioxidation and regulating autophagy

• DOI: 10.1111/jcmm.17153
• Publication Date: 2022-01-19T10:58:32Z
• Authors: Xiaoli Tang; Yuming Zhao; Yanan Liu; Yang Liu; Yue Liu; Fenxi Niu; Fang Fang
• Keywords: Neurotoxicity; Pathogenesis

Abstract The aggregation of β‐amyloid (Aβ) has the neurotoxicity, which is thought to play critical role in pathogenesis Alzheimer's disease (AD). Inhibiting Aβ deposition and neurotoxicity been considered as an important strategy for AD treatment. 3,6'‐Disinapoyl sucrose (DISS), one oligosaccharide esters derived from traditional Chinese medicine Polygalae Radix, possesses antioxidative activity, neuroprotective effect anti‐depressive activity. This study was explore whether DISS could attenuate pathological changes 1‐42 transgenic Caenorhabditis elegans ( C . ). results showed that (5 50 μM) treatment significantly prolonged life span, increased number egg‐laying, reduced paralysis rate, decreased levels lipofuscin ROS attenuated Gene analysis up‐regulate mRNA expression sod ‐ 3 , gst 4 daf 16 bec 1 lgg while down‐regulate 2 15 These suggested protective against ‐induced damages prolongs span may be related reduction by regulating genes antioxidation autophagy.