JUN activation modulates chromatin accessibility to drive TNFα‐induced mesenchymal transition in glioblastoma

• DOI: 10.1111/jcmm.17490
• Publication Date: 2022-07-19T04:30:33Z
• Authors: Xuejiao Lv; Qian Li; Hang Liu; Meihan Gong; Yingying Zhao; Jinyang Hu; Fan Wu; Xudong Wu
• Keywords: Transcription

Abstract Chromatin dynamics as well genetic evolution underlies the adaptability of tumour cells to environmental cues. Three subtypes have been identified in glioblastoma, one commonest malignant brain tumours adults. During progression or under therapeutic pressure, non‐mesenchymal may progress mesenchymal subtype, leading unfavourable prognosis. However, molecular mechanisms for this transition remain poorly understood. Here taking a TNFα‐induced cellular model, we profile chromatin accessibility during transition. Moreover, identify JUN family key driving transcription factors gained accessibility. Accordingly, inhibition phosphorylation and therefore its activity successfully impedes remodelling In line with these findings based on experimental models, is positively correlated features clinical glioblastoma specimens. Together, study unveils deregulated regulatory network hopefully provides rationale anti‐glioblastoma therapy.