Crevicular fluid biomarkers and periodontal disease progression

• DOI: 10.1111/jcpe.12194
• Publication Date: 2013-11-07T11:36:19Z
• Authors: Janet S. Kinney; Thiago Morelli; Min Oh; Thomas M. Braun; Christoph A. Rams...; Jim V. Sugai; William V. Gianno...
• Keywords: Bleeding on probing; Fusobacterium nucleatum; Clinical attachment loss

Assess the ability of a panel gingival crevicular fluid (GCF) biomarkers as predictors periodontal disease progression (PDP).In this study, 100 individuals participated in 12-month longitudinal investigation and were categorized into four groups according to their status. GCF, clinical parameters saliva collected bi-monthly. Subgingival plaque serum bi-annually. For 6 months, no treatment was provided. At patients received therapy continued participation from 12 months. GCF samples analysed by ELISA for MMP-8, MMP-9, Osteoprotegerin, C-reactive Protein IL-1β. Differences median levels compared between stable progressing participants using Wilcoxon Rank Sum test (p = 0.05). Clustering algorithm used evaluate oral classify either or progressing.Eighty-three completed 6-month monitoring phase. With exception protein, all significantly higher PDP group patients. analysis showed highest sensitivity when biofilm pathogens combined with measures, 74% (95% CI 61, 86).Signature fluid-derived measures provides sensitive measure discrimination (ClinicalTrials.gov NCT00277745).