Prolonged multimodal fasting modulates periodontal inflammation in female patients with metabolic syndrome: A prospective cohort study

• DOI: 10.1111/jcpe.13419
• Publication Date: 2021-01-04T09:29:40Z
• Authors: Christina Laetiti...; Nico Steckhan; Daniela Hoedke; Søren Jepsen; Geralinde Rauch; Theresa Keller; Andreas Michalsen; Henrik Dommisch
• Keywords: Inflammation; Male; Metabolic Syndrome; fasting; 610; Fasting; Gingival Crevicular Fluid; bleeding on probing; metabolic syndrome; C-reactive protein; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; gingival crevicular fluid; periodontal inflammation; Humans; Female; Prospective Studies; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

AbstractAimTo determine the potential anti‐inflammatory effect of a multimodal periodic fasting programme on surrogate parameters of periodontal inflammation in hospitalized patients diagnosed for metabolic syndrome (MetS).Material and methodsA total of 47 patients were recruited and hospitalized in an integrative ward for an intensified two‐week multimodal fasting, diet and lifestyle programme. Patients were periodontally examined at baseline (t1), after the 2‐week fasting protocol (t2) and, subsequently, 4 months after fasting (t3). The following parameters were determined: periodontal screening index (PSI), bleeding on probing (BOP), gingival crevicular fluid volume (GCF), plaque index (PI), C‐reactive protein (CRP), blood pressure (BP), waist circumference (WC), fasting glucose (FGLU), triglycerides (TRG), high‐density lipoprotein (HDL) and HbA1c.ResultsA total of 28 female and 8 male patients fulfilled the defined criteria for MetS and were analysed separately by gender. At t2, BOP and GCF were reduced when compared to t1 (median: t2 = 39; t1 = 33.1%; p < .001 and t2 = 73.9; t1 = 59.3 Periotron units p = .02, respectively). BOP reduction correlated to FGLU (R = .37, p = .049) and weight reduction (R = .4, p = .04).ConclusionThis study showed for the first time that clinically supervised periodic fasting in female patients with MetS may facilitate the reduction of periodontal inflammation.