Recombinant bone matrix maintains the graft space, induces vascularized bone regeneration and preserves canine tooth extraction socket structure

• DOI: 10.1111/jcpe.13915
• Publication Date: 2023-12-19T02:54:05Z
• Authors: Ai Okamura; Takahiro Hiratsuka; Hideo Fushimi; Ichiro Nishimura
• Keywords: Cancellous bone; Matrix (chemical analysis)

Abstract Aim Recombinant bone matrix (RBM) is a newly conceived and engineered porous graft granule of average size 600 μm composed purified recombinant collagen peptide. We sought to examine the behaviour with time RBM that was grafted in canine tooth extraction socket. Materials Methods The socket hemisectioned mandibular third premolar distal root granules, whereas opposite side served as non‐grafted control. samples were harvested at 1, 3 6 months healing subjected micro‐CT imaging decalcified paraffin‐embedded histology. Separately, effect compared deproteinized cancellous bovine (DCBB) atelocollagen plug (BACP) model healing. Results maintained space gingival connective tissue until new formed within its space. regenerated highly vascularized continued mature, while completely bioresorbed by months. buccal lingual alveolar ridge heights RBM‐grafted better preserved than those control sockets. degree preservation equivalent DCBB, although their mechanisms different. Conclusions This study demonstrated induced controlled active regeneration structure model. Bioresorbable without animal or human source materials presents novel category robust regenerative property.