A proprietary herbal medicine (5‐Ling Granule) for Tourette syndrome: a randomized controlled trial

• DOI: 10.1111/jcpp.12432
• Publication Date: 2015-06-13T06:44:40Z
• Authors: Yi Zheng; Zhang‐Jin Zhang; Xin‐Min Han; Ying Ding; Yu‐Yan Chen; Xue‐Feng Wang; Xiao‐Wei Wei; Min‐Jie Wang; Yan Cheng; Zhao‐Hong Nie; Min Zhao; Xi‐Xi Zheng
• Keywords: Tiapride

Tourette syndrome (TS) is a common tic disorder in children and adolescents. There preliminary evidence that herbal medicine may possess the potential to treat tics. The purpose of this study was formally evaluate efficacy safety 5-Ling Granule (5-LGr), proprietary polyherbal product, for treatment patients with TS comparison tiapride placebo. In multisite, double-blind, double-dummy, randomized, placebo-controlled trial, 603 aged 5-18 years were randomly assigned placebo (n = 117), 123, 200-400 mg/day) or 5-LGr 363, 15-22.5 g/day) 8 weeks. primary outcome measured using Yale Global Tic Severity Scale (YGTSS) its subscales, total Score (TTS) tic-related impairment. Incidence adverse events compared among three groups. While tics all reduced over time, produced significantly greater improvement on YGTSS overall scale subscale TTS impairment at endpoint than Seventy-four percentage arm 68.3% had clinical response these rates higher those (44.0%, p < .001). incidence fewer (11.2% 13.8% vs. 26.0%, .002); particular physical tiredness, dizziness sleep disturbance. comparable reducing Its profile better tiapride. can be considered safe effective therapy (Trial registration: www.clinicaltrials.gov: NCT01501695).