Polypharmacy in elderly patients in Japan: Analysis of Japanese real‐world databases

• DOI: 10.1111/jcpt.13122
• Publication Date: 2020-01-27T17:08:46Z
• Authors: Takayuki Mabuchi; Kouichi Hosomi; Satoshi Yokoyama; Mitsutaka Takada
• Keywords: Adult; Aged, 80 and over; Adolescent; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Age Factors; Middle Aged; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Japan; Polypharmacy; Adverse Drug Reaction Reporting Systems; Humans; Drug Interactions; Child; Aged; Retrospective Studies

What is known and objective Polypharmacy associated with an increased risk of adverse drug reactions (ADRs) interactions, decreased adherence to medication medical cost. Recently, polypharmacy has become a major problem in care Japan as result the increase ageing population. The purpose this study was investigate current situation association between events. Methods A retrospective data analysis performed using two different real-world from 2007 2015 Japan. Japanese Adverse Drug Event Report (JADER), public spontaneous reaction database constructed by Pharmaceuticals Medical Devices Agency (PMDA), large prescription vendor (Japan Information Research Institute, Inc [JMIRI]) were analysed. Trends during period investigated. Results discussion mean number drugs per report JADER JMIRI databases ranged 4.8 5.6 3.5 3.7, respectively. age both databases, peak at 80-89 years (5.74 drugs) 90-99 (4.97 database. new conclusions until 90 or more, even though events are more likely occur after 80 Therefore, elderly should be focused on patients aged ≥80 rather than ≥65 viewpoint prevention