Marked decrease of tacrolimus blood concentration caused by compound Chinese herbal granules in a patient with refractory nephrotic syndrome

• DOI: 10.1111/jcpt.13256
• Publication Date: 2020-09-25T15:39:07Z
• Authors: Peipei Yang; Fan He; Mei Tan; Fazhan Zhong; Xin Liao; Yingjie Li; Hui Deng; Xiaolan Mo
• Keywords: Refractory (planetary science)

What is known and objective The blood concentration of tacrolimus can be affected by co-administrated drugs. to draw more attention herb-drug interactions in China, where herbal medicines are commonly used. Case description a girl with refractory nephrotic syndrome decreased nearly half despite no change dose. Nebulizer therapy, cyclophosphamide compound Chinese medicine were the only additional treatments than usual. new conclusion most possible cause decrease was administration Radix Astragali among granules.