Role of vitamin D in energy and bone metabolism in postmenopausal women with type 2 diabetes mellitus: A 6‐month follow‐up evaluation

• DOI: 10.1111/jdi.12666
• Publication Date: 2017-04-03T20:33:39Z
• Authors: Makiko Ogata; Naoko Iwasaki; Risa Ide; Miho Takizawa; Mizuho Tanaka; Tamaki Tetsuo; Asako Sato; Yasuko Uchigata
• Keywords: Bone remodeling; Procollagen peptidase; Glycated hemoglobin

Resting energy expenditure was associated with a serum bone turnover marker in postmenopausal women type 2 diabetes (T2DMPW) the present cross-sectional study. To clarify fundamental pathological factor for correlation of metabolism and basal diabetes, 6-month prospective follow-up study carried out supplementation vitamin D.A total 44 T2DMPW were enrolled. The following factors evaluated at beginning end summer: procollagen 1 N-terminal propeptide, carboxy-terminal collagen crosslinks-1, intact parathyroid hormone 25-hydroxyvitamin D (25[OH]D), as well diabetic complications, body composition, respiratory quotient resting expenditure. A 23 patients low 25(OH)D levels (˂20 ng/mL) instructed to increase by lifestyle change. Among them, 15 osteoporosis also administered alfacalcidol.Serum increased 25 decreased 19 patients. Patients who did not receive intervention start tended have 2525(OH)D level; therefore, average level all changed. Changes positively correlated those propeptide/carboxy-terminal crosslinks-1. mean glycated hemoglobin levels; propeptide after intervention. These correlations prominent alfacalcidol supplementation.Restoration might be prerequisite normal between T2DMPW. Lifestyle retention is important even summer,