Independent links between plasma xanthine oxidoreductase activity and levels of adipokines

• DOI: 10.1111/jdi.12982
• Publication Date: 2018-12-05T12:05:11Z
• Authors: Masato Furuhashi; Megumi Matsumoto; Takayo Murase; Takashi Nakamura; Yukimura Higashiura; Masayuki Koyama; Marenao Tanaka; Norihito Moniwa; Hirofumi Ohnishi; Shigeyuki Saitoh; Kazuaki Shimamoto; Tetsuji Miura
• Keywords: Male; 0301 basic medicine; 0303 health sciences; Inslin resistance; Xanthine Dehydrogenase; Articles; Middle Aged; RC648-665; Fatty Acid-Binding Proteins; Diseases of the endocrine glands. Clinical endocrinology; Cohort Studies; Fibroblast Growth Factors; 03 medical and health sciences; Adipokine; Humans; Female; Adiponectin; Obesity; Insulin Resistance; Uric acid; Biomarkers; Follow-Up Studies

Xanthine oxidoreductase (XOR) is a rate-limiting enzyme that catalyzes uric acid formation in the purine metabolism, involved an increase reactive oxygen species. Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance.The association between plasma activity, measured by using liquid chromatography mass spectrometry, levels of adipokines, including adiponectin, fatty acid-binding protein 4 (FABP4) fibroblast growth factor 21 (FGF21), was investigated 282 participants (male/female: 126/156) Tanno-Sobetsu Study who were not taking medication.Women had lower than did men. Smoking habit increased activity. positively correlated concentrations FABP4 (r = 0.192, P < 0.001) FGF21 0.208, 0.001), homeostasis model assessment resistance as index acid, negatively adiponectin level -0.243, 0.001). Multivariate regression analyses showed independent determinants after adjusting age, sex, resistance. With additional adjustment smoking habit, FABP4, but or FGF21, remained predictor activity.Plasma independently adipokines general population individuals medication.