Independent links between plasma xanthine oxidoreductase activity and levels of adipokines
Male
0301 basic medicine
0303 health sciences
Inslin resistance
Xanthine Dehydrogenase
Articles
Middle Aged
RC648-665
Fatty Acid-Binding Proteins
Diseases of the endocrine glands. Clinical endocrinology
Cohort Studies
Fibroblast Growth Factors
03 medical and health sciences
Adipokine
Humans
Female
Adiponectin
Obesity
Insulin Resistance
Uric acid
Biomarkers
Follow-Up Studies
DOI:
10.1111/jdi.12982
Publication Date:
2018-12-05T12:05:11Z
AUTHORS (12)
ABSTRACT
Xanthine oxidoreductase (XOR) is a rate-limiting enzyme that catalyzes uric acid formation in the purine metabolism, involved an increase reactive oxygen species. Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance.The association between plasma activity, measured by using liquid chromatography mass spectrometry, levels of adipokines, including adiponectin, fatty acid-binding protein 4 (FABP4) fibroblast growth factor 21 (FGF21), was investigated 282 participants (male/female: 126/156) Tanno-Sobetsu Study who were not taking medication.Women had lower than did men. Smoking habit increased activity. positively correlated concentrations FABP4 (r = 0.192, P < 0.001) FGF21 0.208, 0.001), homeostasis model assessment resistance as index acid, negatively adiponectin level -0.243, 0.001). Multivariate regression analyses showed independent determinants after adjusting age, sex, resistance. With additional adjustment smoking habit, FABP4, but or FGF21, remained predictor activity.Plasma independently adipokines general population individuals medication.
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