Trends in the effects of pre‐transplant diabetes on mortality and cardiovascular events after kidney transplantation

• DOI: 10.1111/jdi.13397
• Publication Date: 2020-09-25T15:30:30Z
• Authors: Ja Young Jeon; Soo Jung Kim; Kyoung Hwa Ha; Ji Hyun Park; Bumhee Park; Chang‐Kwon Oh; Seung Jin Han
• Keywords: Adult; Male; Articles; Kaplan-Meier Estimate; Middle Aged; RC648-665; Kidney Transplantation; Diseases of the endocrine glands. Clinical endocrinology; 3. Good health; Kidney transplantation; 03 medical and health sciences; Diabetes mellitus; Postoperative Complications; Treatment Outcome; 0302 clinical medicine; Cardiovascular Diseases; Risk Factors; Preoperative Period; Diabetes Mellitus; Humans; Female; Mortality; Proportional Hazards Models; Retrospective Studies

AbstractAims/IntroductionIt is not clear whether survival in kidney transplant recipients with pre‐transplant diabetes has improved over the past decades. We compared the rates of mortality and major adverse cardiovascular events (MACE) after renal transplantation in patients with and without pre‐transplant diabetes. Furthermore, we investigated whether transplant era and recipient age affected the association between diabetes status and adverse events.Materials and MethodsThis retrospective cohort study included 691 patients who underwent renal transplantation between 1994 and 2016 at a single tertiary center. We compared the incidences of post‐transplant mortality and four‐point MACE in patients with and without pre‐transplant diabetes using Kaplan–Meier analysis and the Cox proportional hazard model, and assessed the interactions between diabetes status and transplant era and recipient age.ResultsOf 691 kidney recipients, 143 (20.7%) had pre‐transplant diabetes. The mean follow‐up duration was 94.5 months. Kaplan–Meier analysis showed that patients with pre‐transplant diabetes had higher incidences of post‐transplant mortality and four‐point MACE compared with those without pre‐transplant diabetes (log–rank test, P < 0.001 for both). After adjusting for potential confounding factors, pre‐transplant diabetes was associated with an increased risk of post‐transplant mortality and four‐point MACE (hazard ratio 1.90, 95% confidence interval 1.05–3.44, P = 0.034; and hazard ratio 1.75; 95% confidence interval 1.02–3.00, P = 0.043, respectively). The associations between pre‐transplant diabetes status and all‐cause mortality and four‐point MACE were not affected by transplant era or recipient age.ConclusionsPre‐transplant diabetes remains a significant risk factor for mortality and four‐point MACE in kidney transplant recipients.