Impact of maternal overweight/obesity and high fasting plasma glucose on adverse perinatal outcomes in early gestational diabetes mellitus

• DOI: 10.1111/jdi.14411
• Publication Date: 2025-01-25T05:44:11Z
• Authors: Noriyuki Iwama; Maki Yokoyama; Hiroshi Yamashita; Kei Miyakoshi; Ichiro Yasuhi; Maki Kawasaki; Naoko Arata; Shiori Sato; Yuko Iimura; Waguri Masako; Haruna Kawaguchi; Naoki Masaoka; Yoshiyuki Nakajima; Yuji Hiramatsu; Takashi Sugiyama
• Keywords: Early gestational diabetes mellitus; Fasting plasma glucose; RC648-665; Diseases of the endocrine glands. Clinical endocrinology; Overweight/obesity

ABSTRACT Aim To elucidate risk factors associated with adverse perinatal outcomes in early‐gestational diabetes mellitus (GDM). Materials and Methods A dataset of 385 early‐GDM cases from a prospective cohort was analyzed. Early‐GDM diagnosed if one or more the following criteria were met: fasting plasma glucose (PG) levels 92–125 mg/dL, 1‐h PG ≥180 2‐h ≥153 mg/dL during 75‐g oral tolerance test before 20 weeks gestation. Multivariate analysis used to examine associations between candidate composite outcome maternal neonatal events. Results Pre‐pregnancy overweight/obesity (pre‐pregnancy body mass index [BMI] ≥25.0 kg/m 2 ) significantly higher compared normal weight BMI 18.5–24.9 ), an adjusted ratio (aRR) 1.44 (95% confidence interval [CI]: 1.08–1.93), difference (aRD) 13.6% CI: 2.6–24.6%). Compared below 92 95 125 outcome, aRR aRD 1.42 1.01–1.99) 12.9% 0.3–25.5%), respectively. Conclusions Early‐GDM, combined pre‐pregnancy and/or 95–125 is should be prioritized for intervention.