Lymphocyte subsets and Langerhans cells in the skin of kidney transplant recipients under three different immunosuppressive regimens

• DOI: 10.1111/jdv.18430
• Publication Date: 2022-07-16T10:44:46Z
• Authors: M.V. Quaresma; L.S. Azevedo; N.V. Pereira; M.G. Saldanha; E. David‐Neto; M.N. Sotto
• Keywords: Immunosuppression; Everolimus; Sirolimus

Abstract Background Renal transplant recipients (RTRs) are at increased risk of developing skin cancer; however, the role immunosuppression is not yet fully understood. In this study, we evaluated immunohistochemical changes in RTRs under three different regimens: mTOR inhibitors (mTORi), sirolimus or everolimus, mycophenolic acid (MPA) precursors such as mycophenolate sodium mofetil, azathioprine (AZA). Methods We biopsies sun‐exposed and sun‐protected for quantification B lymphocytes (CD20 + ), T (CD3 , CD4 CD8 Langerhans cells (LCs) (CD1a ) 30 10 healthy controls. The were divided into groups: mTORi ( n = 10), MPA AZA 10). Results No differences observed number lymphocytes. However, a significant decrease LCs was both groups, although to lesser degree latter group. group did differ from that control terms LCs. Conclusions Patients treated with exhibit preserved cellular elements related cutaneous immune surveillance. use induced greater than group, demonstrated by