Longitudinal analysis of the skin microbiome in association with hand eczema, hand hygiene practices and moisturizer use

• DOI: 10.1111/jdv.19906
• Publication Date: 2024-02-29T07:16:15Z
• Authors: H. K. Vindenes; C. Drengenes; H. Amin; K. Irgens‐Hansen; C. Svanes; R. J. Bertelsen
• Keywords: Moisturizer

Abstract Background The skin microbiota maintains a physical and immunological barrier to the environment. Little is known about how microbiome changes over time or effect of hand hygiene practices moisturizer use. Objectives To assess sex‐specific in bacteria time, related self‐reported eczema, use moisturizers. Methods Swab samples from dorsal were collected at baseline 6.5 years later during COVID‐19 pandemic, 168 participants RHINESSA study Bergen, Norway. analysed by 16S rRNA amplicon sequencing. Results alpha diversity increased follow‐up, beta differed sex both points. relative abundance for several with differences. Current eczema aggravating pandemic associated an increase Staphylococcus . High washing frequency home was lower higher , Corynebacterium Finegoldia Pseudomonas Propionibacterium Pelomonas increasing passing between sampling, whereas more frequent significantly diversity, change some bacteria, such as Conclusions This longitudinal revealed overall microbial 6‐year period, which unexpected since follow‐up performed when vigorous hygienic introduced. Sex‐specific differences identified Individuals seem develop dysbiotic bacterial community time. Hand moisturizers, typically gender‐specific habitual patterns, may lead composition.