Luteolin improves hypercholesterolemia and glucose intolerance through LXRα‐dependent pathway in diet‐induced obese mice

• DOI: 10.1111/jfbc.13358
• Publication Date: 2020-06-29T20:16:25Z
• Authors: Hee‐Sook Park; Kyunhee Lee; Soon‐Hee Kim; Moon Ju Hong; Nam‐Joo Jeong; Myung‐Sunny Kim
• Keywords: 2. Zero hunger; 0301 basic medicine; Mice; 0303 health sciences; 03 medical and health sciences; Glucose Intolerance; Hypercholesterolemia; Animals; Mice, Obese; Luteolin; Orphan Nuclear Receptors; ATP Binding Cassette Transporter 1; Diet

Luteolin, a naturally derived flavonoid, exerts beneficial effects such as antitumor, antioxidant, and anti-inflammatory effects. However, the molecular mechanism underlying effect of luteolin in hypercholesterolemia remains unclear. In this study, we demonstrated that upregulated expression liver X receptor (LXR) α, ATP-binding cassette transporter G1 (ABCG1), scavenger class B member 1 (SRB1), which play major role cholesterol efflux, HepG2 hepatocytes. Luteolin-stimulated ABCG1 SRB1 was reversed by inhibitory compound LXRα. Luteolin administration also ABCG1, well 7 α-hydroxylase (Cyp7α1) diet-induced obese mice. decreased level blood non-high-density lipoprotein addition, ameliorated glucose intolerance reduced gluconeogenesis-associated enzymes an LXRα-dependent manner. Practical applications is known to possess various pharmacological activities. This research revealed ameliorates obesity. The results indicate potential properties metabolism could be explained, at least part, being due through activation receptor, LXRα signaling pathway cells.